Overview
Terbinafine is an antifungal medication used topically to treat common dermatophyte infections. It works by inhibiting fungal ergosterol synthesis, leading to fungal cell death. The cream formulation is applied directly to affected skin areas for 1-2 weeks depending on infection location.
Mechanism of Action
Terbinafine inhibits squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. This inhibition causes accumulation of squalene and depletion of ergosterol, disrupting fungal cell membrane integrity and leading to fungal cell death.
Indications
- Treatment of athlete's foot (tinea pedis)
- Treatment of jock itch (tinea cruris)
- Treatment of ringworm (tinea corporis)
Common Doses
- 1% cream
Dosage
Adults and children ≥12 years: Apply to affected area twice daily for athlete's foot between toes (1 week) or on bottom/sides of foot (2 weeks), and once daily for jock itch/ringworm (1 week). Wash and dry area before application. Children <12 years: Consult physician.
Contraindications
- Hypersensitivity to terbinafine or any component of the formulation
Side Effects
- Local irritation
- Burning
- Itching
- Dryness
- Rash
- Contact dermatitis
Interactions
- No significant drug interactions reported with topical administration
Counseling Points
- Wash and dry affected area thoroughly before application
- Apply thin layer to affected skin only
- Wash hands after application
- Wear well-ventilated shoes and change socks daily for athlete's foot
- Complete full course of treatment even if symptoms improve
- Avoid occlusive dressings unless directed by physician