Overview
Prifinium Bromide is an antispasmodic and anticholinergic agent used primarily for gastrointestinal disorders. It acts as a competitive antagonist at muscarinic acetylcholine receptors, reducing smooth muscle spasms and gastrointestinal motility. It's commonly prescribed for conditions involving gastrointestinal hypermotility and spasms.
Mechanism of Action
Competitive antagonist of muscarinic acetylcholine receptors (anticholinergic). It blocks parasympathetic nerve impulses in smooth muscles of the gastrointestinal tract, reducing spasms, motility, and gastric secretions.
Indications
- Irritable bowel syndrome (IBS)
- Gastrointestinal spasms
- Peptic ulcer disease (adjunct therapy)
- Gastritis
- Colitis
- Biliary dyskinesia
Dosage
Adults: Typically 30-60 mg 3-4 times daily before meals. Maximum daily dose: 240 mg. Children: Dosage based on weight (consult prescribing information). Should be taken 30 minutes before meals.
Contraindications
- Hypersensitivity to prifinium bromide or anticholinergics
- Glaucoma (angle-closure)
- Prostatic hypertrophy with urinary retention
- Gastrointestinal obstruction
- Myasthenia gravis
- Severe ulcerative colitis
- Tachycardia
Side Effects
- Dry mouth
- Blurred vision
- Constipation
- Dizziness
- Headache
- Tachycardia
- Urinary retention
- Nausea
- Drowsiness
- Flushing
Interactions
- Other anticholinergic drugs (additive effects)
- Tricyclic antidepressants
- Antihistamines
- Antipsychotics
- MAO inhibitors
- Digoxin (increased absorption)
- Ketoconazole (decreased absorption)