Overview
Pancreatin is a pancreatic enzyme supplement containing lipase, protease, and amylase derived from porcine pancreas. It is used to replace deficient exocrine pancreatic enzymes in conditions like cystic fibrosis, chronic pancreatitis, and pancreatic insufficiency. The enzymes aid in digestion of fats, proteins, and carbohydrates in the gastrointestinal tract.
Mechanism of Action
Pancreatin contains pancreatic enzymes (lipase, protease, amylase) that replace deficient endogenous pancreatic enzymes. Lipase hydrolyzes triglycerides to monoglycerides and fatty acids, protease cleaves proteins into peptides and amino acids, and amylase converts starch to dextrins and sugars, facilitating normal digestion and nutrient absorption.
Indications
- Exocrine pancreatic insufficiency due to cystic fibrosis
- Chronic pancreatitis
- Pancreatectomy
- Other conditions causing pancreatic enzyme deficiency
Common Doses
- Creon: 3,000-6,000 lipase units/kg/meal for cystic fibrosis
- Typical adult dose: 25,000-80,000 lipase units per meal
- Drops: 10 drops sublingually 2-3 times daily (as per source)
Dosage
Dosage is individualized based on weight, age, diet, and degree of pancreatic insufficiency. Typically administered with meals and snacks. For the specific product in the source: Adults and children ≥12 years: 10 drops sublingually 2-3 times daily or as directed. Consult physician for children <12 years.
Contraindications
- Hypersensitivity to pork proteins or any component
- Acute pancreatitis or acute exacerbations of chronic pancreatitis
Side Effects
- Abdominal pain
- Flatulence
- Diarrhea
- Nausea
- Vomiting
- Constipation
- Headache
- Dizziness
- Allergic reactions (rash, itching, anaphylaxis)
Interactions
- Antacids containing calcium carbonate or magnesium hydroxide may reduce efficacy
- May decrease absorption of iron supplements
- Possible interaction with acarbose or miglitol (theoretical)
Counseling Points
- Take with meals or snacks for optimal effect
- Do not crush or chew enteric-coated formulations
- Store at room temperature away from moisture
- Report severe abdominal pain, persistent diarrhea, or allergic reactions
- Maintain adequate hydration