Overview
Mupirocin is a topical antibiotic ointment used to treat skin infections caused by susceptible strains of Staphylococcus aureus and Streptococcus pyogenes. It works by inhibiting bacterial protein synthesis and is primarily indicated for impetigo. The medication is applied topically three times daily for up to 10 days.
Mechanism of Action
Mupirocin is a bacteriostatic antibiotic that reversibly binds to bacterial isoleucyl-tRNA synthetase, inhibiting protein synthesis in susceptible bacteria.
Indications
- Topical treatment of impetigo due to Staphylococcus aureus
- Topical treatment of impetigo due to Streptococcus pyogenes
Common Doses
- 2% ointment
Dosage
Apply a small amount of mupirocin ointment to the affected area three times daily for up to 10 days. Cover with gauze dressing if desired. Re-evaluate patients not showing clinical response within 3-5 days.
Contraindications
- Known hypersensitivity to mupirocin
- Known hypersensitivity to any excipients in mupirocin ointment
Side Effects
- Severe allergic reactions
- Eye irritation
- Local irritation
- Clostridium difficile-associated diarrhea
Interactions
- No significant drug-drug interactions reported for topical mupirocin
Counseling Points
- Use only on skin - avoid eyes, nose, mouth, and other mucous membranes
- Apply exactly as directed, typically 3 times daily
- Complete full course of treatment even if symptoms improve
- Do not mix with other topical products
- Wash hands before and after application
- Cover treated area with gauze if desired