Overview
Mometasone furoate is a potent corticosteroid used primarily for its anti-inflammatory and immunosuppressive effects. It is commonly prescribed for dermatological conditions like eczema and psoriasis, as well as respiratory conditions including asthma and allergic rhinitis. The drug works by reducing inflammation and immune responses at the application site.
Mechanism of Action
Mometasone furoate is a synthetic glucocorticoid receptor agonist that binds to intracellular glucocorticoid receptors, leading to anti-inflammatory effects through inhibition of inflammatory mediator production, decreased vascular permeability, and suppression of immune cell migration and activation.
Indications
- Atopic dermatitis (eczema)
- Psoriasis
- Allergic rhinitis
- Asthma maintenance therapy
- Other inflammatory dermatoses
Common Doses
- 0.1% cream/ointment/lotion
- 50 mcg per actuation nasal spray
- 100 mcg, 200 mcg, 400 mcg inhalation doses
Dosage
Dosage varies by formulation and indication. For dermatological use: typically apply a thin layer once daily. For respiratory use: inhaled formulations are used once or twice daily depending on severity. Always use the lowest effective dose for the shortest duration.
Contraindications
- Hypersensitivity to mometasone or any component of the formulation
- Active untreated fungal, bacterial, or viral infections at application site
- Systemic fungal infections
- Recent live virus vaccination in immunocompromised patients
Side Effects
- Local: burning, itching, dryness, folliculitis
- Systemic: adrenal suppression, hypercorticism
- Respiratory: oral candidiasis, hoarseness
- Ophthalmic: increased intraocular pressure, cataracts
- Dermatological: skin atrophy, striae, telangiectasia
- Metabolic: hyperglycemia
Interactions
- No clinically significant drug interactions identified in clinical trials
- Concurrent use with other corticosteroids may increase systemic effects
- Strong CYP3A4 inhibitors may theoretically increase systemic exposure
Counseling Points
- Apply thin layer only to affected areas for dermatological use
- Do not use occlusive dressings unless directed
- Rinse mouth after inhaled use to prevent oral candidiasis
- Report any signs of infection or lack of improvement
- Do not discontinue abruptly with long-term use
- Use exactly as prescribed; do not exceed recommended dose