Overview
Miconazole is an antifungal medication used to treat various fungal infections. It works by inhibiting ergosterol synthesis in fungal cell membranes, leading to cell death. This specific formulation is indicated for veterinary use in dogs and cats.
Mechanism of Action
Miconazole inhibits the synthesis of ergosterol, an essential component of fungal cell membranes, by blocking the enzyme lanosterol 14α-demethylase. This disruption compromises membrane integrity and function, leading to fungal cell death.
Indications
- Treatment of fungal infections in dogs and cats caused by Microsporum canis
- Treatment of fungal infections in dogs and cats caused by Microsporum gypseum
- Treatment of fungal infections in dogs and cats caused by Trichophyton mentagrophytes
Common Doses
- 1% concentration
Dosage
Apply a light covering to affected areas once daily for 2 to 4 weeks. Avoid contact with eyes and wash hands thoroughly after administration to prevent spread of infection.
Contraindications
- Hypersensitivity to miconazole or any component of the formulation
Side Effects
- Local irritation at application site
- Contact dermatitis
- Pruritus
- Erythema
Interactions
- May interact with other antifungal agents
- Potential interactions with drugs metabolized by CYP450 enzymes
Counseling Points
- Apply only to affected areas as directed
- Complete full course of treatment even if symptoms improve
- Wash hands thoroughly after application
- Avoid contact with eyes and mucous membranes
- Store at room temperature away from moisture and heat