Overview
Methocarbamol is a centrally-acting skeletal muscle relaxant used as adjunctive therapy for acute musculoskeletal pain. Its exact mechanism is not fully understood but appears related to CNS depression rather than direct muscle relaxation. It provides symptomatic relief when combined with rest and physical therapy.
Mechanism of Action
Methocarbamol's pharmacological action is not clearly identified but may be related to its sedative properties. It does not directly relax tense skeletal muscles but appears to exert its effects through central nervous system depression.
Indications
- Adjunct to rest, physical therapy, and other measures for relief of discomfort associated with acute, painful musculoskeletal conditions
Common Doses
- 500 mg tablets
Dosage
Adults: Initial dosage of 1500 mg (3 tablets of 500 mg) four times daily. For severe conditions, up to 8 grams daily may be administered initially. After 48-72 hours, dosage can usually be reduced to approximately 4 grams daily. Maintenance dosage is typically 1000 mg (2 tablets) four times daily.
Contraindications
- Hypersensitivity to methocarbamol or any tablet components
Side Effects
- Drowsiness, dizziness, lightheadedness
- Nausea, vomiting, dyspepsia
- Headache, blurred vision, diplopia
- Hypotension, bradycardia, flushing
- Rash, pruritus, urticaria
- Anaphylactic reaction, angioneurotic edema
- Leukopenia, jaundice
- Seizures, confusion, amnesia
Interactions
- Potentiates effects of alcohol and other CNS depressants
- May inhibit pyridostigmine bromide - use with caution in myasthenia gravis patients on anticholinesterase agents
Counseling Points
- May cause drowsiness or dizziness - avoid driving or operating machinery until effects are known
- Avoid alcohol and other CNS depressants
- Take with food if gastrointestinal upset occurs
- Use only as directed for acute conditions, not for chronic use
- Report any signs of allergic reaction or unusual side effects