Overview
Mebeverine hydrochloride is an antispasmodic agent used primarily for the treatment of irritable bowel syndrome (IBS) and other functional gastrointestinal disorders. It acts directly on the smooth muscle of the gastrointestinal tract to relieve spasms without affecting normal gut motility.
Mechanism of Action
Mebeverine is a musculotropic antispasmodic with a direct action on the smooth muscle of the gastrointestinal tract. It inhibits the influx of calcium ions into smooth muscle cells, which prevents muscle contraction and reduces spasms. Unlike anticholinergic agents, it does not affect normal gut motility.
Indications
- Irritable bowel syndrome (IBS)
- Gastrointestinal spasm
- Abdominal pain and cramping associated with functional bowel disorders
Dosage
Adults: 135 mg three times daily, preferably 20 minutes before meals. The dose may be reduced to 135 mg twice daily once symptoms improve. The tablets should be swallowed whole with water, not chewed or crushed.
Contraindications
- Hypersensitivity to mebeverine or any component of the formulation
- Paralytic ileus
- Severe hepatic impairment
Side Effects
- Headache
- Dizziness
- Nausea
- Constipation
- Allergic reactions (rash, urticaria, angioedema)
- Abdominal discomfort
Interactions
- No significant drug interactions have been reported
- Theoretical interaction with other antispasmodics may enhance effects