Overview
Mebeverine is an antispasmodic medication used to treat functional gastrointestinal disorders, particularly irritable bowel syndrome (IBS). It acts directly on the smooth muscle of the gastrointestinal tract to relieve spasms and associated pain without affecting normal gut motility.
Mechanism of Action
Mebeverine is a musculotropic antispasmodic with a direct action on the smooth muscle of the gastrointestinal tract. It inhibits phosphodiesterase, leading to increased intracellular cyclic adenosine monophosphate (cAMP), which causes smooth muscle relaxation. Unlike anticholinergic agents, it does not affect autonomic nervous system function.
Indications
- Symptomatic relief of irritable bowel syndrome (IBS)
- Relief of abdominal pain and cramps
- Treatment of spastic conditions of the colon
Dosage
Adults: 135 mg three times daily, preferably 20 minutes before meals. The dosage may be reduced to 135 mg twice daily once symptoms improve. Not recommended for children under 10 years.
Contraindications
- Hypersensitivity to mebeverine or any component of the formulation
- Paralytic ileus
- Severe hepatic impairment
Side Effects
- Headache
- Dizziness
- Nausea
- Constipation
- Allergic reactions (rash, urticaria, angioedema)
- Abdominal discomfort
Interactions
- No significant drug interactions reported in standard references
- Theoretical interaction with other antispasmodics may enhance effects