Overview
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic properties. It is used to manage pain and inflammation in various conditions, including osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders.
Mechanism of Action
Ketoprofen inhibits cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Acute musculoskeletal disorders
- Dysmenorrhea
- Postoperative pain
Dosage
Adults: 100-200 mg daily in divided doses. Maximum daily dose: 200 mg. Elderly or renal impairment: lower doses may be required. Always follow prescribing information.
Contraindications
- Hypersensitivity to ketoprofen or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe heart failure
- Third trimester of pregnancy
- Severe renal impairment
Side Effects
- Gastrointestinal: nausea, dyspepsia, abdominal pain, diarrhea, ulceration
- Cardiovascular: edema, hypertension
- Renal: elevated creatinine, acute renal failure
- Hepatic: elevated liver enzymes
- Central nervous system: headache, dizziness
- Dermatological: rash, photosensitivity
Interactions
- Anticoagulants (e.g., warfarin): increased risk of bleeding
- ACE inhibitors/ARBs: reduced antihypertensive effect and renal impairment
- Diuretics: reduced diuretic efficacy and renal impairment
- Lithium: increased lithium levels
- Methotrexate: increased methotrexate toxicity
- Other NSAIDs or corticosteroids: increased gastrointestinal risk