Overview
Desription Hydroxocobalamin Injection is a sterile, red-colored, preservative-containing injectable solution supplied as a multi-dose vial for intramuscular administration. Hydroxocobalamin is a naturally occurring form of vitamin B12 essential for normal hematopoiesis, neurologic function, and cellular metabolism. Each mL contains: Hydroxocobalamin ..............................
Mechanism of Action
Desription Hydroxocobalamin Injection is a sterile, red-colored, preservative-containing injectable solution supplied as a multi-dose vial for intramuscular administration. Hydroxocobalamin is a naturally occurring form of vitamin B12 essential for normal hematopoiesis, neurologic function, and cellular metabolism. Each mL contains: Hydroxocobalamin .............................. 1 mg Benzyl Alcohol .................................. 0.9% Sodium Chloride ................................ 9 mg Sterile Water for Injection .............. q.s. The pH is adjusted with hydrochloric acid and/or sodium hydroxide to a target pH range of 4.0 to 7.5. Hydroxocobalamin appears as dark red crystals or crystalline powder and is sparingly soluble in water. The solution should appear clear and red in color.
Common Doses
- Refer to label
Dosage
Refer to FDA label for detailed dosing.
Contraindications
- Contraindications Hydroxocobalamin Injection is contraindicated in patients with known hypersensitivity to hydroxocobalamin, vitamin B12 preparations, cobalt, benzyl alcohol, or any component of the formulation. Hypersensitivity reactions, including anaphylactic shock and serious allergic reactions, have been reported following parenteral administration of hydroxocobalamin and other vitamin B12 products. Administration to patients with hereditary optic nerve atrophy (Leber’s disease) may result in severe and rapid optic nerve atrophy.
Side Effects
- Adverse Reactions The following adverse reactions have been reported with hydroxocobalamin injection and other parenteral vitamin B12 products: Hypersensitivity reactions including anaphylactic shock, urticaria, rash, pruritus, flushing, and edema Injection site pain, erythema, and injection site reactions Headache and dizziness Nausea and diarrhea Fever and chills Rare cases of hypokalemia during intensive treatment of severe megaloblastic anemia Serious hypersensitivity reactions, including anaphylaxis, may occur in sensitive patients.
Interactions
- No major interactions listed on the FDA label. Always consult a healthcare professional.