Overview
Esomeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells. It is indicated for the treatment of frequent heartburn occurring two or more days per week, with full effect typically achieved within 1-4 days of daily use. This medication is not intended for immediate relief of heartburn symptoms.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that irreversibly binds to and inhibits the H+/K+ ATPase enzyme system (proton pump) at the secretory surface of gastric parietal cells, thereby suppressing gastric acid secretion.
Indications
- Treatment of frequent heartburn (occurs 2 or more days per week)
Common Doses
- 20 mg
Dosage
Adults 18 years and older: Take one 20 mg delayed-release tablet once daily before eating in the morning for 14 days. Swallow whole with water; do not crush or chew. May repeat 14-day course every 4 months if needed. Do not exceed one tablet daily or use for more than 14 days without medical direction.
Contraindications
- Hypersensitivity to esomeprazole or any component of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Flatulence
- Constipation
- Dry mouth
- Dizziness
Interactions
- Drugs dependent on gastric pH for absorption (e.g., ketoconazole, iron salts, digoxin)
- Clopidogrel (esomeprazole may reduce antiplatelet activity)
- Methotrexate (esomeprazole may increase methotrexate levels)
- St. John's wort and rifampin (may decrease esomeprazole levels)
Counseling Points
- Take once daily before eating in the morning
- Swallow tablet whole with water; do not crush or chew
- May take 1-4 days for full effect
- Not for immediate heartburn relief
- Complete full 14-day course as directed
- Do not exceed recommended dosage or duration without medical advice