Overview
Cefdinir is a third-generation cephalosporin antibiotic used to treat mild to moderate bacterial infections. It works by inhibiting bacterial cell wall synthesis and is effective against various Gram-positive and Gram-negative organisms. The drug is typically administered orally with a standard total daily dose of 600 mg.
Mechanism of Action
Cefdinir is a bactericidal cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and leading to cell lysis and death.
Indications
- Community-acquired pneumonia caused by susceptible strains
- Acute exacerbations of chronic bronchitis
- Acute maxillary sinusitis
- Pharyngitis/tonsillitis
- Uncomplicated skin and skin structure infections
Common Doses
- 300 mg
- 600 mg
Dosage
Total daily dose is 600 mg, administered as 300 mg twice daily or 600 mg once daily depending on infection type. Duration ranges from 5-10 days. Can be taken without regard to meals.
Contraindications
- Known allergy to cephalosporin class antibiotics
Side Effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Vaginal candidiasis
- Rash
- Elevated liver enzymes
Interactions
- Antacids containing aluminum or magnesium may reduce absorption
- Iron supplements may decrease bioavailability
- Probenecid may increase cefdinir concentrations
Counseling Points
- Complete full course of therapy even if symptoms improve
- May be taken with or without food
- Report severe diarrhea, abdominal pain, or signs of allergic reaction immediately
- Inform healthcare provider of all medications being taken
- Store at room temperature