Overview
Azilsartan/Chlorthalidone is a fixed-dose combination antihypertensive medication containing an angiotensin II receptor blocker (ARB) and a thiazide-like diuretic. It is used for the treatment of hypertension when combination therapy is appropriate. The combination provides additive blood pressure reduction through complementary mechanisms.
Mechanism of Action
Azilsartan selectively blocks the binding of angiotensin II to the AT1 receptor, inhibiting vasoconstriction and aldosterone secretion. Chlorthalidone inhibits sodium reabsorption in the distal convoluted tubule of the kidney, increasing excretion of sodium and water, and reducing plasma volume.
Indications
- Treatment of hypertension
Dosage
Available as azilsartan medoxomil/chlorthalidone 40/12.5 mg and 40/25 mg tablets. Initial dose: 40/12.5 mg once daily. May increase to 40/25 mg if needed. Maximum dose: 40/25 mg daily. Take with or without food.
Contraindications
- Anuria
- Hypersensitivity to azilsartan, chlorthalidone, or other sulfonamide-derived drugs
- Concomitant use with aliskiren in patients with diabetes
Side Effects
- Dizziness
- Fatigue
- Hypotension
- Increased serum creatinine
- Hyperuricemia
- Hypokalemia
- Headache
- Diarrhea
- Nausea
- Muscle spasms
Interactions
- Lithium (increased lithium toxicity)
- NSAIDs (reduced antihypertensive effect, renal impairment)
- Other antihypertensives (additive effects)
- Corticosteroids (hypokalemia)
- Digoxin (hypokalemia may increase toxicity)
- Cholestyramine/colestipol (reduced absorption)