Overview
Azelaic Acid Gel 15% is a topical medication indicated for the treatment of inflammatory papules and pustules of mild to moderate rosacea. It is applied twice daily and works by reducing inflammation and normalizing keratinization. The medication is minimally absorbed systemically, making it generally well-tolerated.
Mechanism of Action
Azelaic acid exhibits antimicrobial, anti-inflammatory, and comedolytic properties. It reduces inflammation by inhibiting reactive oxygen species production from neutrophils and normalizes keratinization in follicular epithelium.
Indications
- Topical treatment of inflammatory papules and pustules of mild to moderate rosacea (15% gel or foam)
- • Topical treatment of acne vulgaris (20% cream)
Common Doses
- 15% gel
Dosage
Apply a thin layer to affected facial areas twice daily (morning and evening) after cleansing. Wash hands immediately after application. Cosmetics may be applied after gel has dried. Reassess if no improvement after 12 weeks. More detailes:Rosacea (15% gel or foam) Apply a thin layer to affected areas of the face twice daily (morning and evening) after cleansing and drying the skin. Acne Vulgaris (20% cream) Apply to affected areas twice daily after cleansing and drying the skin. • Wash hands after application. • Cosmetics may be applied after product dries. • Clinical improvement may take several weeks. • Reassess therapy if no improvement after 12 weeks.
Contraindications
- Hypersensitivity to azelaic acid or any component of the formulation
Side Effects
- Burning/stinging (commonly reported)
- Pruritus
- Dryness
- Erythema
- Peeling
- Contact dermatitis
Interactions
- Avoid concomitant use with other topical acne/rosacea medications unless directed by physician
- May increase irritation when used with abrasive cleansers, alcohol-based products, or peeling agents
Counseling Points
- Cleanse skin with mild soap before application
- Apply thin layer twice daily to affected areas only
- Wash hands immediately after application
- Avoid contact with eyes, mouth, and mucous membranes
- Cosmetics may be applied after gel dries
- Use sunscreen as rosacea may worsen with sun exposure
- Report severe irritation or lack of improvement after 12 weeks