Overview
Alfuzosin is an alpha-1 adrenergic receptor antagonist used primarily for the treatment of benign prostatic hyperplasia (BPH). It works by relaxing smooth muscle in the prostate and bladder neck, improving urinary flow and reducing symptoms. It is typically administered as an extended-release formulation taken once daily.
Mechanism of Action
Alfuzosin selectively blocks alpha-1 adrenergic receptors in the prostate, bladder neck, and urethra, leading to relaxation of smooth muscle tissue. This reduces urethral resistance and improves urinary flow in patients with benign prostatic hyperplasia.
Indications
- Treatment of signs and symptoms of benign prostatic hyperplasia (BPH)
Common Doses
- 10 mg
Dosage
10 mg extended-release tablet taken orally once daily, immediately after the same meal each day. Tablets should be swallowed whole and not crushed or chewed.
Contraindications
- Hypersensitivity to alfuzosin or any component of the formulation
- Moderate or severe hepatic impairment
- Concomitant use with potent CYP3A4 inhibitors
- History of orthostatic hypotension
Side Effects
- Dizziness
- Headache
- Fatigue
- Upper respiratory tract infection
- Postural hypotension
- Syncope
- Tachycardia
- Nausea
- Abdominal pain
Interactions
- Potent CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir) - contraindicated
- Other alpha-adrenergic blockers - increased risk of hypotension
- Phosphodiesterase-5 inhibitors - potential additive blood pressure lowering effects
- Antihypertensive medications - may enhance hypotensive effects
Counseling Points
- Take medication after the same meal each day
- Swallow tablet whole - do not crush or chew
- Rise slowly from sitting or lying position to minimize dizziness
- Avoid driving or operating machinery if experiencing dizziness
- Report any fainting episodes to healthcare provider
- Do not take with grapefruit juice