Overview
Adapalene is a topical retinoid medication primarily used for the treatment of acne vulgaris. It works by normalizing follicular keratinization and reducing inflammation. The cream formulation is applied once daily to affected skin areas.
Mechanism of Action
Adapalene is a synthetic retinoid that binds to specific retinoic acid nuclear receptors, modulating cellular differentiation, keratinization, and inflammatory processes. It normalizes the differentiation of follicular epithelial cells, prevents microcomedone formation, and reduces inflammatory lesions.
Indications
- Topical treatment of acne vulgaris
Common Doses
- 0.1% cream
Dosage
Apply a thin film to affected areas once daily at nighttime. Use enough to lightly cover the entire affected area. A mild transitory sensation of warmth or slight stinging may occur after application.
Contraindications
- Hypersensitivity to adapalene or any components of the cream vehicle
Side Effects
- Erythema (mild to severe)
- Scaling
- Dryness
- Pruritus (itching)
- Burning/stinging sensation
- Sunburn
- Skin irritation
- Acne flare
- Dermatitis/contact dermatitis
- Eyelid edema
- Conjunctivitis
- Skin discoloration
- Rash
- Eczema
Interactions
- Concomitant use with other potentially irritating topical products (medicated/abrasive soaps, strong drying cosmetics, high-alcohol products, astringents)
- Use with caution with preparations containing sulfur, resorcinol, or salicylic acid
- Avoid starting therapy until effects of previous irritating preparations have subsided
Counseling Points
- Apply once daily at bedtime to clean, dry skin
- Use sunscreen daily as adapalene may increase sun sensitivity
- Apply a thin layer only; more is not better
- Avoid contact with eyes, lips, and mucous membranes
- Mild irritation is common initially and usually improves with continued use
- Do not use on broken, sunburned, or eczematous skin
- Allow skin to dry completely before application
- Results may take 8-12 weeks to become apparent