Overview
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used for the symptomatic treatment of inflammatory and painful conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It works by inhibiting cyclooxygenase enzymes, reducing prostaglandin synthesis and providing analgesic and anti-inflammatory effects. The drug is typically administered as a once-daily oral formulation.
Mechanism of Action
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exerts its pharmacological effects primarily through inhibition of cyclooxygenase (COX) enzymes, particularly COX-2. This inhibition reduces the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. The drug provides analgesic, anti-inflammatory, and antipyretic properties.
Indications
- Rheumatoid arthritis
- Ankylosing spondylitis
- Osteoarthritis
- Periarthritis of scapulohumeral joint
- Lumbago
- Ischiadynia
- Pain caused by non-articular rheumatism
Common Doses
- 200 mg
Dosage
The recommended adult dose is 200 mg daily, taken as a single dose every 24 hours. Dose and frequency may be modified under physician or pharmacist supervision based on individual patient response and tolerability.
Contraindications
- Hypersensitivity to aceclofenac, diclofenac, or other NSAIDs
- History of asthma attacks induced by NSAIDs or aspirin
- Active peptic ulcer disease
- Patients with acute rhinitis or urticaria triggered by prostaglandin synthesis inhibitors
Side Effects
- Gastrointestinal disorders (dyspepsia, abdominal pain, nausea)
- Rash
- Erythema
- Urticaria
- Headache
- Dizziness
- Drowsiness
- Symptoms of enuresis
- Increased risk of gastrointestinal bleeding and ulceration
- Renal impairment
- Hepatic enzyme elevation
Interactions
- Close monitoring required with lithium and digoxin
- Oral antidiabetic agents may require dose adjustment
- Anticoagulants (increased bleeding risk)
- Diuretics (reduced antihypertensive effect)
- Other analgesics (additive effects)
- Methotrexate (increased toxicity risk)
- Cyclosporine (increased nephrotoxicity risk)
Counseling Points
- Take with food or milk to minimize gastrointestinal upset
- Do not crush or chew extended-release tablets
- Report any signs of gastrointestinal bleeding (black stools, vomiting blood)
- Monitor for signs of allergic reactions (rash, itching, swelling)
- Avoid alcohol consumption during treatment
- Inform healthcare provider of all medications being taken
- Do not use during third trimester of pregnancy
- Report any unusual bruising or bleeding